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학술지 Microdevice for Separation of Circulating Tumor Cells Using Embedded Magnetophoresis with V-shaped Ni-Co Nanowires and Immuno-nanomagnetic Beads
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저자
박정원, 이내림, 조성목, 정문연, 임춘화, 이대식
발행일
201504
출처
ETRI Journal, v.37 no.2, pp.233-240
ISSN
1225-6463
출판사
한국전자통신연구원 (ETRI)
DOI
https://dx.doi.org/10.4218/etrij.15.0114.0572
협약과제
13SC2100, CDx용 Liquid Biopsy Device 개발 , 이대식
초록
The novelty of this study resides in a 6"-wafer-level microfabrication protocol for a microdevice with a fluidic control system for the separation of circulating tumor cells (CTCs) from human whole blood cells. The microdevice utilizes a lateral magnetophoresis method based on immunomagnetic nanobeads with anti-epithelial cell adhesive molecule antibodies that selectively bind to epithelial cancer cells. The device consists of a top polydimethylsiloxane substrate for microfluidic control and a bottom substrate for lateral magnetophoretic force generation with embedded v-shaped soft magnetic microwires. The microdevice can isolate about 93% of the spiked cancer cells (MCF-7, a breast cancer cell line) at a flow rate of 40/100 mL/min with respect to a whole human blood/buffer solution. For all isolation, it takes only 10 min to process 400 mL of whole human blood. The fabrication method is sufficiently simple and easy, allowing the microdevice to be a mass-producible clinical tool for cancer diagnosis, prognosis, and personalized medicine.
키워드
Breast cancer, Cancer diagnosis, Circulating tumor cells, Microfluidic, Ni-Co electroplating
KSP 제안 키워드
Blood cells, Breast Cancer(BC), Breast cancer cell line, Buffer solution, Cancer Diagnosis, Circulating tumor cells(CTC), Co nanowires, Control systems, Epithelial cells, Fabrication method, Flow rate