생체 시료를 이용한 알츠하이머 질병의 진단 방법
송기봉, 김창범, 김관수
- 9541561 (2017.01.10)
11SF1300, 생체진단 가능 시각/미각 수용체 기반 센싱 기술 개발,
- Provided is a method for diagnosing Alzheimer/s disease using a decomposed biomaterial. The method includes: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid; binding the beta-amyloid to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which a photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid existing in the biomaterial.
- KSP 제안 키워드
- Beta-amyloid, Field-effect transistors(FETs), Fluorescent material(FM), field effect, magnetic particles, s disease