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학술지 Label-Free Optical Biosensing Using a Horizontal Air-Slot SiNx Microdisk Resonator
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저자
이신영, 음석찬, 장지수, 허철, 성건용, 신중훈
발행일
201009
출처
Optics Express, v.18 no.20, pp.20638-20644
ISSN
1094-4087
출판사
Optical Society of America(OSA)
DOI
https://dx.doi.org/10.1364/OE.18.020638
협약과제
10ZC1100, 메가컨버전스 핵심기술 개발, 함호상
초록
We demonstrate label-free optical biosensing using a horizontal air-slotted silicon-rich silicon nitride (SiNx) microdisk resonator. Due to the strong confinement of light in the air-slot, a large resonance shift of 6.2 nm is observed upon reaction of the biotin-functionalized disk with a streptavidin solution with concentration of 2.5 μg/ml. Assuming a linear relationship between resonance shift and streptavidin concentration, we estimate the sensitivity to be 2.5 짹 0.2 nm/(μg/ml). Comparing this value with surface sensitivity of 5.7 nm/nm calculated using FDTD simulations, a detection limit of 30 짹 2 ng/ml, is extrapolated. © 2010 Optical Society of America.
KSP 제안 키워드
Detection limit, FDTD simulation, Label-Free, Resonance shift, Sensitivity to, Silicon-rich silicon nitride, linear relationship, microdisk resonator, optical biosensing, surface sensitivity