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학술지 2-Substitued-Pyridazin-3(2H)-Ones as Green Electrophilic Agents in Synthesis
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저자
성기현, 김보람, 이상경, 김점종, 윤용진
발행일
201204
출처
Current Organic Chemistry, v.16 no.7, pp.852-858
ISSN
1385-2728
출판사
Bentham Science Publishers
DOI
https://dx.doi.org/10.2174/138527212800194773
협약과제
12ZK1100, 그린IT 융.복합 기술개발, 이수인
초록
Pyridazin-3(2H)-ones are inexpensive, stable, and easily prepared heterocycles. Since pyridazin-3(2H)-ones readily form stable anions, and can act as good leaving group. Their utility as synthetic auxiliaries was recently demonstrated by Yoon's group. 2-Substituted-pyridazin-3(2H)-ones are also useful both the electrophilic agents and equivalents for the functionalization of the electron rich compounds and active methylenes, and synthones. 2-Substituted-pyridazin-3(2H)-ones are novel green agents because that can be recovered quantitatively and recycled. In this review, the preparation and the synthetic application of 2-substituted-pyridazin-3(2H)-ones are described. © 2012 Bentham Science Publishers.
키워드
2-substitutedpyridazin-3(2H)-one, Acylation, Coupling agent, Cyanation, Electrophilic halogenation, Lactonization, N-arylsulfonation, N-nitration
KSP 제안 키워드
Coupling agent, Electron-rich, Form stable, Leaving group, electrophilic halogenation