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학술지 CMOS Image Sensor for Detection of Interferon Gamma Protein Interaction as a Point-of-Care Approach
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저자
Mohana Marimuthu, Karthikeyan Kandasamy, 안창근, 성건용, 김민곤, 김상효
발행일
201112
출처
Analytical and Bioanalytical Chemistry, v.401 no.5, pp.1645-1653
ISSN
1618-2642
출판사
Springer
DOI
https://dx.doi.org/10.1007/s00216-011-5231-9
협약과제
11ZC1100, 메가컨버전스 핵심기술 개발, 함호상
초록
Complementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility of incorporating them into portable diagnostic devices. The present research examined the efficiency and sensitivity of a CMOS image sensor for the detection of antigen-antibody interactions involving interferon gamma protein without the aid of expensive instruments. The highest detection sensitivity of about 1 fg/ml primary antibody was achieved simply by a transmission mechanism. When photons are prevented from hitting the sensor surface, a reduction in digital output occurs in which the number of photons hitting the sensor surface is approximately proportional to the digital number. Nanoscale variation in substrate thickness after protein binding can be detected with high sensitivity by the CMOS image sensor. Therefore, this technique can be easily applied to smartphones or any clinical diagnostic devices for the detection of several biological entities, with high impact on the development of point-of-care applications. © 2011 Springer-Verlag.
키워드
CMOS sensors, Immunoassays, Indium nanoparticles, Interferon gamma, Photon
KSP 제안 키워드
Antigen-antibody, CMOS Sensor, CMOS image sensor, Complementary metal-oxide-semiconductor(CMOS), Detection sensitivity, Diagnostic devices, Digital output, High Sensitivity, High impact, Indium nanoparticles(In NPs), Interferon gamma