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학술지 Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics
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저자
정재웅, Jordan G. McCall, Gunchul Shin, Yihui Zhang, Ream Al-Hasani, Minku Kim, Shuo Li, 심주용, Kyung-In Jang, Yan Shi, Daniel Y. Hong, Yuhao Liu, Gavin P. Schmitz, Li Xia, Zhubin He, Paul Gamble, Wilson Z. Ray, Yonggang Huang, Michael R. Bruchas, John A. Rogers
발행일
201507
출처
Cell, v.162 no.3, pp.662-674
ISSN
0092-8674
출판사
Cell Press
DOI
https://dx.doi.org/10.1016/j.cell.2015.06.058
협약과제
15ZC1700, 광간섭계 기반의 광음향 기술을 이용한 무채혈 혈당분석 원천기술 , 김봉규
초록
In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, untethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (μ-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.
KSP 제안 키워드
Cellular signaling, Drug Delivery, Fiber optic, Freely moving, Gene expression, Interface technology, Minimally invasive, Neural circuits, Neural interface, Orders of magnitude, light-emitting diode(LED)