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Journal Article Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics
Cited 412 time in scopus Share share facebook twitter linkedin kakaostory
Authors
Jae-Woong Jeong, Jordan G. McCall, Gunchul Shin, Yihui Zhang, Ream Al-Hasani, Minku Kim, Shuo Li, Joo Yong Sim, Kyung-In Jang, Yan Shi, Daniel Y. Hong, Yuhao Liu, Gavin P. Schmitz, Li Xia, Zhubin He, Paul Gamble, Wilson Z. Ray, Yonggang Huang, Michael R. Bruchas, and John A. Rogers
Issue Date
2015-07
Citation
Cell, v.162, no.3, pp.662-674
ISSN
0092-8674
Publisher
Cell Press
Language
English
Type
Journal Article
DOI
https://dx.doi.org/10.1016/j.cell.2015.06.058
Abstract
In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, untethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (μ-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.
KSP Keywords
Cellular signaling, Drug Delivery, Fiber optic, Freely moving, Interface technology, Minimally invasive, Neural circuit, Neural interface, Orders of magnitude, gene expression, light emitting diodes(LED)