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학술지 Enhanced Protein Immobilization Efficiency on a TiO2 Surface Modified with a Hydroxyl Functional Group
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저자
김완중, 김상희, 이봉수, 김안순, 아칠성, 허철, 성건용, 윤완수
발행일
200910
출처
Langmuir, v.25 no.19, pp.11692-11697
ISSN
0743-7463
출판사
American Chemical Society(ACS)
DOI
https://dx.doi.org/10.1021/la901615e
협약과제
08MC2500, 유비쿼터스 건강관리용 모듈 시스템, 박선희
초록
An antibody immobilization was investigated using a self-assembled monolayer (SAM) over the highly refractive coatings with a SiO2, TiO2, or Si3N4 substrate. The immobilization was characterized by analyzing the hydrophilic properties of hydroxyl (OH) groups on surface coatings with contact angle (CA) measurements to enhance protein immobilization. The hydroxyl (OH) group was formed in greater amounts as the oxygen plasma exposure time was increased, which resulted in a large enhancement in antibody immobilization. It indicated that hydroxyl (OH) group formation is critical for developing a label-free optical transducer with a high sensitivity. © 2009 American Chemical Society.
KSP 제안 키워드
Contact angle(CA), Exposure time, Group Formation, High Sensitivity, Hydrophilic properties, Hydroxyl functional group, Label-Free, Optical transducer, Refractive coatings, Surface-modified, antibody immobilization