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학술지 A Simple Method for Quantification of Beta-Amyloid Using the Photo-Sensitive Thin Film Transistor
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저자
김관수, 주종일, 조정민, 성희경, 송기봉
발행일
201105
출처
Advanced Materials Research, v.254, pp.58-61
ISSN
1662-8985
출판사
Trans Tech Publications
DOI
https://dx.doi.org/10.4028/www.scientific.net/AMR.254.58
협약과제
11SF1300, 생체진단 가능 시각/미각 수용체 기반 센싱 기술 개발, 송기봉
초록
This paper reports a technique for quantification of beta-amyloid protein by the use of photo sensitive thin film transistor (p-TFT). In recent studies, a beta-amyloid protein has strongly related a central role of the pathogenesis of Alzheimer's disease (AD) and AD-related olfactory sensory loss. In the p-TFT, we observed the difference of the photo-current according to the presence of the particles with beta-amyloid, RAW 264.7 cells, and olfactory receptor neuron cells. The p-TFT shows the drain current reduction of about 50μA is caused by the RAW 264.7 cells with magnetic beads and beta-amyloid. Therefore, we suggest a new method of detecting small quantity of A-beta for early diagnosis of AD by using photo-sensitive thin film transistor (p-TFT) devices. © (2011) Trans Tech Publications, Switzerland.
키워드
Alzheimer's disease, Beta-amyloid, Photo-sensitive thin film transistor (p-TFT)
KSP 제안 키워드
Alzheimer's Disease(AD), Beta-amyloid, Drain current, Early diagnosis, Magnetic beads(MBs), Neuron cells, Olfactory receptor neuron, Photo-current, Photo-sensitive, RAW 264.7 cells, Thin-Film Transistor(TFT)