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학술지 A Three-Dimensional and Bevel-Angled Ultrahigh Aspect Ratio Microneedle for Minimally Invasive and Painless Blood Sampling
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저자
이대식, Cheng Guo Li, 임춘화, 정형일
발행일
201802
출처
Sensors and Actuators B : Chemical, v.255, pp.384-390
ISSN
0925-4005
출판사
Elsevier
DOI
https://dx.doi.org/10.1016/j.snb.2017.08.030
협약과제
17JS1300, 다중 바이오마커 기반 모바일 다이어트 모니터링 기술 개발, 이대식
초록
In spite of the invasiveness and pain related with it, blood sampling is necessary in point-of-care systems to obtain biochemical information. In this context, a substitute micro-scale needle for minimally invasive and painless blood sampling has been developed. In conventional microneedle fabrication methods, it is difficult to combine the features of a sharp tip shape, appropriate length, and a hollow structure simultaneously. Thus, here we report a sharp, hollow, and ultrahigh aspect ratio microneedle long enough to get to the blood vessels which is capable of minimizing the pain caused by nerve pricking. It is equipped with a fluidic system to handle blood. The structure of the microneedle was precisely formed using a drawing lithography method and a sharp angle tip was formed using a laser-cutting method.
KSP 제안 키워드
Blood Vessels, Blood sampling, Cutting method, Fabrication method, Fluidic system, Hollow structure, Laser-cutting, Micro-scale, Minimally invasive, Point-of-care, Sharp angle