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학술지 Fluoropolymer-Based Flexible Neural Prosthetic Electrodes for Reliable Neural Interfacing
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저자
김용희, 박종길, 구호, 김민선, 정상돈
발행일
201711
출처
ACS Applied Materials & Interfaces, v.9 no.50, pp.43420-43428
ISSN
1944-8244
출판사
American Chemical Society(ACS)
DOI
https://dx.doi.org/10.1021/acsami.7b12364
협약과제
17JH1100, 시냅스 소자 학습을 위한 생물학적 뉴런 네트워크 시스템 개발, 정상돈
초록
We covalently bound fluoropolymer (FP) films by plasma treatment followed by thermal pressing at temperatures below their melting point and fabricated an adhesion-metal-free flexible gold electrode array entirely encapsulated by the FP film, excepting the active electrode openings. The fabricated device was chemically resistant and was modified to have a lower impedance and efficient charge injection capability. The fabricated device was evaluated in vivo in rats and was confirmed to record the epidural epileptiform activity induced by chemical administration. The chemically inert nature of FPs and the gold electrode is expected to facilitate reliable neural interfacing without abiotic issues. Plasma treatment-induced covalent binding of FP films can also be utilized in a variety of applications requiring durability, such as implantable biosensors and sensor platforms operating under chemically harsh environments, including humid conditions.
키워드
coadhesion, epidural electrode, fluoropolymers, neural interface, reliability, RF plasma treatment
KSP 제안 키워드
Active electrode, Gold electrodes, Harsh Environment, Humid conditions, Implantable biosensor, Metal-free, Neural interface, RF plasma treatment, Thermal pressing, charge injection, covalent binding