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학술지 Microfluidic Neural Probes: In Vivo Tools for Advancing Neuroscience
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저자
심주용, Matthew P. Haney, 박성일, Jordan G. McCall, 정재웅
발행일
201703
출처
Lab on a Chip, v.17 no.8, pp.1406-1435
ISSN
1473-0197
출판사
Royal Society of Chemistry (RSC)
DOI
https://dx.doi.org/10.1039/C7LC00103G
협약과제
17ZS1300, 광간섭계 기반의 광음향 기술을 이용한 무채혈 혈당분석 원천기술 , 김봉규
초록
Microfluidic neural probes hold immense potential as in vivo tools for dissecting neural circuit function in complex nervous systems. Miniaturization, integration, and automation of drug delivery tools open up new opportunities for minimally invasive implants. These developments provide unprecedented spatiotemporal resolution in fluid delivery as well as multifunctional interrogation of neural activity using combined electrical and optical modalities. Capitalizing on these unique features, microfluidic technology will greatly advance in vivo pharmacology, electrophysiology, optogenetics, and optopharmacology. In this review, we discuss recent advances in microfluidic neural probe systems. In particular, we will highlight the materials and manufacturing processes of microfluidic probes, device configurations, peripheral devices for fluid handling and packaging, and wireless technologies that can be integrated for the control of these microfluidic probe systems. This article summarizes various microfluidic implants and discusses grand challenges and future directions for further developments.
KSP 제안 키워드
Drug Delivery, Fluid handling, Manufacturing processes, Minimally invasive, Neural activity, Neural circuits, Peripheral devices, Wireless technology, future directions, grand challenges, microfluidic probe