상세정보
학술지
One-Pot, Regioselective Consecutive Multihalogenation of 2,2'-Bithiophene
- 저자
- 김보람, 김은정, 성기현, 김점종, 신동수, 이상경, 윤용진
- 발행일
- 201305
- 출처
- European Journal of Organic Chemistry, v.2013 no.14, pp.2788-2797
- ISSN
- 1434-193X
- 초록
- The one-pot regioselective consecutive multihalogenation of 2,2??-bithiophene (1) was demonstrated. Compound 1 was consecutively halogenated with lithium halides such as lithium bromide, chloride, and/or iodide in the presence of lead tetraacetate in chloroform at room temperature or under reflux conditions to give 5-bromo(or chloro)-5??-iodo(or chloro)-, 3-bromo(or chloro)-5,5??-dibromo(or dichloro, diiodo)-, 3,3??-dibromo-(or dichloro)-5,5??-diiodo(or dibromo, dichloro)-, and 3,3??,5-tribromo(or trichloro)-5??-iodo(or bromo)-2,2??- bithiophenes. Notably, this process offers a regioselective method for consecutive multihalogenation in one pot, and the yields and selectivity are also higher than those obtained in the step-by-step and concurrent halogenation methods. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- KSP 제안 키워드
- Co. KGaA, Lithium bromide, One-pot, Room-temperature, Step-by-step