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Portable Guided-Mode Resonance Biosensor Platform for Point-of-Care Testing
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- Authors
- Gun Yong Sung, Wan-Joong Kim, Hyunsung Ko, Bong Kyu Kim, Kyung-Hyun Kim, Chul Huh, Jongcheol Hong
- Issue Date
- 2012-08
- Citation
- Biosensing and Nanomedicine V (SPIE 8460), pp.1-14
- Publisher
- SPIE
- Language
- English
- Type
- Conference Paper
- Abstract
- It represents a viable solution for the realization of a portable biosensor platform that could screen/diagnose acute myocardial infarction by measuring cardiac marker concentrations such as cardiac troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin (MYO) for application to u-health monitoring system. The portable biosensor platform introduced in this presentation has a more compact structure and a much higher measuring resolution than a conventional spectrometer system. Portable guided-mode resonance (GMR) biosensor platform was composed of a biosensor chip stage, an optical pick-up module, and a data display panel. Disposable plastic GMR biosensor chips with nano-grating patterns were fabricated by injection-molding. Whole blood filtration and label-free immunoassay were performed on these single chips, automatically. Optical pick-up module was fabricated by using the miniaturized bulk optics and the interconnecting optical fibers and a tunable VCSEL (vertical cavity surface emitting laser). The reflectance spectrum from the GMR biosensor was measured by the optical pick-up module. Cardiac markers in human serum with concentrations less than 0.1ng/mL were analyzed using a GMR biosensor. Analysis time was 30min, which is short enough to meet clinical requirements. Our results show that the GMR biosensor will be very useful in developing lowcost portable biosensors that can screen for cardiac diseases. © 2012 SPIE.
- KSP Keywords
- Biosensor chips, Biosensor platform, Bulk optics, CK-MB, Cardiac Diseases, Cardiac markers, Creatine kinase mb, Data display, Display Panel, GMR biosensor, Health Monitoring System(HMS)