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학술지 Poly(ethylene glycol)-Functionalized Photocurable Silsesquioxane as an Antibiofouling Material for Nanostructure-Based Biomedical Applications
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이봉국, 김동표, 류진화, 박재훈, 백규하, 도이미
Japanese Journal of Applied Physics, v.52 no.6 PART 2, pp.1-6
Japan Society of Applied Physics (JSAP), Institute of Physics (IOP)
Poly(ethylene glycol)-functionalized silsesquioxane acrylate (PEG-SSQA) has been developed as antibiofouling material for nanostructure-based biomedical applications. PEG-SSQA was synthesized from the hydrolytic condensation of trimethoxysilanes with PEG and acrylate groups. From the NMR spectra, the PEG-SSQA was observed to be a mixture of random, ladder, and cage structures. The cured PEG-SSQA exhibits hydrophilicity (water contact angle: 26.6-34.7), low swelling ratios in water (<1:8 wt %) and organic solvents (<3 wt %), a high UV transparency (>90% at 365 nm), a high Young's modulus (ca. 1 GPa), and low shrinkage (<4:2% in height). PEG-SSQA possessed the ability to form sub- 25nm features. In addition, the cured PEG-SSQA films with long-term stability under chemical and biological stress showed strong resistance to the nonspecific adsorption of proteins. These characteristics may offer a new strategy for the development of a number of biomedical applications, such as nanobiodevices, nanobiosensors and labs-on-a-chip. © 2013 The Japan Society of Applied Physics.
KSP 제안 키워드
65 nm, Adsorption of proteins, Applied physics, Biomedical applications, Contact angle(CA), Hydrolytic condensation, Long-Term Stability, Low shrinkage, Low swelling, NMR Spectra, New strategy