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Journal Article Poly(ethylene glycol)-Functionalized Photocurable Silsesquioxane as an Antibiofouling Material for Nanostructure-Based Biomedical Applications
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Bong Kuk Lee, Kim Dong -Pyo, Jin Hwa Ryu, Park Jae Hoon, Baek Kyu-Ha, Do Lee-Mi
Issue Date
Japanese Journal of Applied Physics, v.52 no.6 PART 2, pp.1-6
Japan Society of Applied Physics (JSAP), Institute of Physics (IOP)
Project Code
12VC1600, Synthesis of Oxide Semiconductor and Insulator Ink Materials and Process Development for Printed Backplane of Flexible Displays Processed Below 150 oC, Do Lee-Mi
Poly(ethylene glycol)-functionalized silsesquioxane acrylate (PEG-SSQA) has been developed as antibiofouling material for nanostructure-based biomedical applications. PEG-SSQA was synthesized from the hydrolytic condensation of trimethoxysilanes with PEG and acrylate groups. From the NMR spectra, the PEG-SSQA was observed to be a mixture of random, ladder, and cage structures. The cured PEG-SSQA exhibits hydrophilicity (water contact angle: 26.6-34.7), low swelling ratios in water (<1:8 wt %) and organic solvents (<3 wt %), a high UV transparency (>90% at 365 nm), a high Young's modulus (ca. 1 GPa), and low shrinkage (<4:2% in height). PEG-SSQA possessed the ability to form sub- 25nm features. In addition, the cured PEG-SSQA films with long-term stability under chemical and biological stress showed strong resistance to the nonspecific adsorption of proteins. These characteristics may offer a new strategy for the development of a number of biomedical applications, such as nanobiodevices, nanobiosensors and labs-on-a-chip. © 2013 The Japan Society of Applied Physics.
KSP Keywords
65 nm, Adsorption of proteins, Applied physics, Biomedical applications, Contact angle(CA), Hydrolytic condensation, Long-Term Stability, Low shrinkage, Low swelling, NMR Spectra, New strategy