상세정보
학술지
EPITRANS: A Database that Integrates Epigenome and Transcriptome Data
- 저자
- 조수영, 채진철, 박수준, 서혜명, 손채봉, 이영식
- 발행일
- 201311
- 출처
- Molecules and Cells, v.36 no.5, pp.472-475
- ISSN
- 1016-8478
- 출판사
- Springer
- 협약과제
- 13VS1300, 유전체 분석용 슈퍼컴퓨팅 시스템 개발, 최완
- 초록
- Epigenetic modifications affect gene expression and thereby govern a wide range of biological processes such as differentiation, development and tumorigenesis. Recent initiatives to define genome-wide DNA methylation and histone modification profiles by microarray and sequencing methods have led to the construction of databases. These databases are repositories for international epigenetic consortiums or provide mining results from PubMed, but do not integrate the epigenetic information with gene expression changes. In order to overcome this limitation, we constructed EPITRANS, a novel database that visualizes the relationships between gene expression and epigenetic modifications. EPITRANS uses combined analysis of epigenetic modification and gene expression to search for cell function-related epigenetic and transcriptomic alterations (Freely available on the web at http://epitrans.org). © The Korean Society for Molecular and Cellular Biology. All rights reserved.
- KSP 제안 키워드
- Biological Processes, Cell function, Cellular Biology, Combined analysis, DNA methylation, Epigenetic modification, Freely available, Gene expression, Genome-wide, Transcriptome data, Wide range