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Is The Biotransformation of Chlorinated Dibenzo-p-dioxins by Sphingomonas wittichii RW1 Governed by Thermodynamic Factors?
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- Authors
- In-Hyun Nam, Hyo-Bong Hong, Stefan Schmidt
- Issue Date
- 2014-12
- Citation
- Journal of Microbiology, v.52, no.9, pp.801-804
- ISSN
- 1225-8873
- Language
- English
- Type
- Journal Article
- Abstract
- Density functional theory (DFT) calculations were used to explore the relationship between the biotransformation of dibenzo-p-dioxin and selected chlorinated derivatives by resting cells of Sphingomonas wittichii RW1 and measuring the thermodynamic properties of the biotransformation substrates. Sphingomonas wittichii RW1 can aerobically catabolize dibenzo-p-dioxin as well as 2,7-dichloro-, 1,2,3-trichloro-, 1,2,3,4-tetrachloro-, and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin; however, neither the 2,3,7-trichloro- nor the 1,2,3,7,8-pentachlorodibenzo-p-dioxin was transformed to its corresponding metabolic intermediate. The experimental biotransformation rates established were apparently governed by the selected thermodynamic properties of the substrates tested.
- KSP Keywords
- As 2, Dibenzo-p-dioxin, Resting cells, Thermodynamic properties, density functional theory (DFT) calculations