BROWSE
Detail
Journal Article
Label-free optical biosensing using a horizontal air-slot SiN_x microdisk resonator
- Authors
- Shinyoung Lee, Seok Chan Eom, Jee Soo Chang, Chul Huh, Gun Yong Sung, Jung H. Shin
- Issue Date
- 2010-09
- Citation
- Optics Express, v.18, no.20, pp.20638-20644
- ISSN
- 1094-4087
- Publisher
- Optical Society of America(OSA)
- Language
- English
- Type
- Journal Article
- Abstract
- We demonstrate label-free optical biosensing using a horizontal air-slotted silicon-rich silicon nitride (SiNx) microdisk resonator. Due to the strong confinement of light in the air-slot, a large resonance shift of 6.2 nm is observed upon reaction of the biotin-functionalized disk with a streptavidin solution with concentration of 2.5 μg/ml. Assuming a linear relationship between resonance shift and streptavidin concentration, we estimate the sensitivity to be 2.5 짹 0.2 nm/(μg/ml). Comparing this value with surface sensitivity of 5.7 nm/nm calculated using FDTD simulations, a detection limit of 30 짹 2 ng/ml, is extrapolated. © 2010 Optical Society of America.
- KSP Keywords
- Detection limit, FDTD simulation, Label-free, Optical biosensing, Resonance shift, Sensitivity to, Silicon-rich silicon nitride, linear relationship, microdisk resonator, surface sensitivity
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
