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Journal Article Oxidation Stiffening of PDMS Microposts
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Authors
Joo Yong Sim, Rebecca E. Taylor, Tom Larsen, Beth L. Pruitt
Issue Date
2015-06
Citation
Extreme Mechanics Letters, v.3, pp.17-23
ISSN
2352-4316
Publisher
Elsevier
Language
English
Type
Journal Article
DOI
https://dx.doi.org/10.1016/j.eml.2015.02.003
Abstract
This paper presents guidance for analyzing the stiffness changes of micropost arrays after oxidation. Numerous mechanobiology studies exploit micropost arrays to quantify cell-generated micropost displacements and traction forces. Cell adhesion requires surface functionalization typically facilitated by an oxidation step, which can form a glassy skin. We estimate the material properties of this skin, analytically calculate the stiffness of oxidized microposts and compare it with direct measurements. We find correction factors increase exponentially with decreasing micropost diameter. Ignoring this oxidation stiffening of microposts results in more than 200% underestimation in micropost stiffness as well as the cellular traction forces extracted from micropost deflections.
KSP Keywords
Cell Adhesion, Direct measurements, Stiffness changes, correction factor, material properties, surface functionalization, traction forces