BROWSE
Detail
Journal Article
CMOS Image Sensor for Detection of Interferon Gamma Protein Interaction as a Point-of-Care Approach
Cited 13 time in 
Share 
Share
- Authors
- Mohana Marimuthu, Karthikeyan Kandasamy, Chang Geun Ahn, Gun Yong Sung, Min-Gon Kim, Sanghyo Kim
- Issue Date
- 2011-12
- Citation
- Analytical and Bioanalytical Chemistry, v.401, no.5, pp.1645-1653
- ISSN
- 1618-2642
- Publisher
- Springer
- Language
- English
- Type
- Journal Article
- Abstract
- Complementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility of incorporating them into portable diagnostic devices. The present research examined the efficiency and sensitivity of a CMOS image sensor for the detection of antigen-antibody interactions involving interferon gamma protein without the aid of expensive instruments. The highest detection sensitivity of about 1 fg/ml primary antibody was achieved simply by a transmission mechanism. When photons are prevented from hitting the sensor surface, a reduction in digital output occurs in which the number of photons hitting the sensor surface is approximately proportional to the digital number. Nanoscale variation in substrate thickness after protein binding can be detected with high sensitivity by the CMOS image sensor. Therefore, this technique can be easily applied to smartphones or any clinical diagnostic devices for the detection of several biological entities, with high impact on the development of point-of-care applications. © 2011 Springer-Verlag.
- KSP Keywords
- Antigen-antibody, CMOS image sensor, Complementary metal-oxide-semiconductor(CMOS), Detection sensitivity, Diagnostic device, Digital output, High Sensitivity, High impact, Interferon gamma, Metal-oxide(MOX), Point-of-care