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Conference Paper A surface plasmon and guided mode microscope for the micro- to nano-thickness imaging
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Authors
H.-B. Pyo, Y.-B. Shin, M.-G. Kim, S.-K. Lee, D.-H. Shin, Y.-J. Kim
Issue Date
2002-10
Citation
International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) / Meeting of the Biomedical Engineering Society (BMES) 2002, pp.1636-1637
Language
English
Type
Conference Paper
DOI
https://dx.doi.org/10.1109/IEMBS.2002.1106576
Abstract
A surface plasmon and guided mode imaging system has been developed and the images of photoresist and of self assembled monolayer (SAM) patterns on a gold-coated sensor chip were obtained, for the thickness level of /spl mu/m down to nm range. For the future development of multiple arrays of a biosensor system it is necessary to investigate the detection limit of the sensor quantitatively. A possible way of detection was presented in that it is possible to construct and to detect the bindings of nucleic acids, enzymes and proteins down to the thickness of nm scale without labeling, with relatively simple and cheap optical components.