현재 생물분자의 기능적 관점에서 단백질 구조에 관심이 많이 모아지고 있다. 단백질의 기능은 구조에서 기인하기 때문에 두 단백질의 구조간의 유사성을 측정할 수 있는 방법은 두 단백질의 기능의 유사성을 유추할 수 있다. 본 논문에서는 두 단백질의 구조의 유사성을 측정하기 위한 단백질의 새로운 표현(representation)으로 3차원 에지 히스토그램을 제안한다. 단백질의 3차원 구조를 작은 복셀(voxel)로 이루어진 공간으로 나누고 복셀들로부터 3차원 에지 히스토그램을 추출하여 두 단백질간의 유사도 계산에 이용한다. 이를 통하여 단백질의 검색 및 분류를 시도한다.
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