현재 생물분자의 기능적 관점에서 단백질 구조에 관심이 많이 모아지고 있다. 단백질의 기능은 구조에서 기인하기 때문에 두 단백질의 구조간의 유사성을 측정할 수 있는 방법은 두 단백질의 기능의 유사성을 유추할 수 있다. 본 논문에서는 두 단백질의 원자간 결합선 분포의 유사성을 기반으로 한 웹 환경에서 동작하는 단백질 구조 검색 시스템을 설계 구현하였다. 두 단백질의 구조의 유사성을 측정하기 위한 단백질의 표현(representation)으로는 3 차원 에지 히스토그램을 사용하였다. 3차원 에지 히스토그램, 즉, 3차원 공간 상에서의 원자간 결합선 분포에 기반한 단백질 구조 검색 시스템은 많은 양의 단백질 구조 정보로부터 원하는 형태의 단백질 구조를 빠른 시간에 검색할 수 있는 장점을 가지므로 스크리닝의 전단계(pre-screening)에서 사용될 수 있다.
KSP Keywords
pre-screening
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