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Multiplexed Polymer Surface Plasmon Sensor with Integrated Optical Coupler
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- Authors
- Hyeon-Bong Pyo, Se Ho Park, Kwang Hyo Chung, Chang Auck Choi
- Issue Date
- 2005-10
- Citation
- Smart Medical and Biomedical Sensor Technology III (SPIE 6007), v.6007, pp.1-10
- Publisher
- SPIE
- Language
- English
- Type
- Conference Paper
- Abstract
- In this paper, we describe a novel multiplexed surface plasmon resonance (SPR) sensor which is made of cyclic olefin copolymers (COCs, Topas?꽓) This material has excellent chemical resistance, low water uptake (< 0.01%), and high refractive index (nHe-Ne = 1.53) suitable to use as an optical coupler (prism) as well as a sensor substrate. We fabricated a standard slide glass sized, prism integrated, and injection molded COC-SPR sensor which is being applied toward the multiplexed detection of DNA single nucleotide polymorphism (SNP). To evaluate the sensitivity of COC-SPR sensor, we first patterned MgF2 on gold-coated COC-SPR sensor and observed the shift of minimum reflectivity (SPR dip) in pixel address. As incident light source we used an expanded, collimated, rectangular shaped He-Ne laser, with a diffuser for beam homogenization. With expanded laser beam we varied incident angle so that the angular shift is expressed as the darkest pixel shift on CCD. For optimized SPR characteristics and sensor configuration, analytical calculations (Fresnel equation) were performed, and the best SPR conditions were found to be dAu ~ 48 nm at wavelength {\\lambda} = 633 nm with respected resonance angle at 罐SPR = 44.2째 for COC-SPR sensor.
- KSP Keywords
- Analytical calculations, Beam homogenization, Chemical resistance, Detection of DNA, He-ne laser, Incident angle, Laser beams, Light sources, Low water, Minimum reflectivity, Pixel shift