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Toxicity Bioassay in Sprague -Dawley Rats Exposed to 20 kHzTriangular Magnetic Field for 90 Days
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- Authors
- Sung Ho Kim, Hae June Lee, Soo Yong Choi, Youn Myoung Gimm, Jeong Ki Pack, Hyung Do Choi, Yun Sil Lee
- Issue Date
- 2006-02
- Citation
- Bioelectromagnetics, v.27, no.2, pp.105-111
- ISSN
- 0197-8462
- Publisher
- John Wiley & Sons
- Language
- English
- Type
- Journal Article
- Project Code
- 06MR2200, A Study on electromagnetic effects and standardization, Choi Hyung Do
- Abstract
- Sprague-Dawley rats (10 each of male and female per group for sham and magnetic field exposed) were exposed in a carrousel irradiator to 20 kHz intermediate frequency (IF) magnetic field at 6.25 μT rms for 8 h/day, 5 days/week for 90 days. Urine analysis (pH, serum glucose, protein, ketone bodies, RBC, WBC, bilirubin, urobilinogen, and specific gravity), blood analysis [WBC, RBC, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), thrombocyte count, and leucocyte count], blood biochemistry (total protein, blood urea nitrogen, creatinine, glucose, total bilirubin, total cholesterol, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase), and histopathological analysis for organs such as liver, kidney, testis, ovary, spleen, brain, heart, and lung were performed on day 90. Results showed no significant differences in the above analyses between IF magnetic field exposed and sham control rats. Therefore, we conclude that there were no significant toxicities in rats exposed to 20 kHz IF triangular magnetic field-exposure for 90 days. © 2005 Wiley-Liss, Inc.
- KSP Keywords
- Alanine aminotransferase, Alkaline phosphatase(ALP), Aspartate aminotransferase, Blood analysis, Blood biochemistry, Intermediate frequency, Lactate dehydrogenase(LDH), Magnetic field(MF), Mean corpuscular hemoglobin concentration, Serum glucose, Specific gravity