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Plastic-Silicon PCR Amplification System Made Using Microfabrication Technologies
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- Authors
- Dae Sik Lee, Se Ho Park, Kwang Hyo Chung, Hyeon Bong Pyo
- Issue Date
- 2006-10
- Citation
- IEEE Sensors 2006, pp.592-595
- Publisher
- IEEE
- Language
- English
- Type
- Conference Paper
- Abstract
- We present a novel polyimide micro-heat control system, embedding with a micro heater and a temperature sensor, and silicon reaction chamber for polymerase chain reaction (PCR). We have demonstrated a precise heat control, and rapid thermal response in the chip, and the chip successfully amplified PCR of a genomic DNA template (breast cancer suppressor gene, BRCA 1 127 base pairs) in a 3 μI-volume chamber within 18 min, extracted from the human whole blood, and it is applicable a lab-on-a-chip for precise, fast, efficient and cost-effective DNA analysis, including biomedical applications and disease diagnostics. © 2006 IEEE.
- KSP Keywords
- Base pairs, Biomedical applications, Breast Cancer(BC), DNA Analysis, DNA template, Genomic DNA, Heat control system, Human whole blood, Lab on a Chip(LoC), Micro-heater, Microfabrication technologies