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Conference Paper Precipitation Biosensor based on Lab-Chip Accomplishing Self-Fluid Replacements Via Capillary Force
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Authors
Kwang Hyo Chung, Jung Woo Hong, Jun Hwang Lee, Hyeon Bong Pyo, Byung Woo Kim, Hyun C. Yoon
Issue Date
2006-11
Citation
International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) 2006, pp.341-343
Language
English
Type
Conference Paper
Abstract
A novel polymer microfluidic chip for sample exchange via capillary force and a test of the device for an enzyme-catalyzed precipitation reaction are described. All the fluidic actuations in the device were run by a time-planned flow sequence and accomplished by only capillary force. The chip accomplishing self-replacement of samples was realized by designing the channels with theoretically derived equations for the capillary flow and stop. The chip was fabricated with polymer replication techniques which are suitable for the device fabrication with low price and single use. The test for a biochemical analysis using biocatalyzed precipitation reaction with the chip showed desired outcome. The presented microfluidic method would be applicable to various biochemical lab-chips with integrated washing steps or fluid replacement steps.
KSP Keywords
Biocatalyzed precipitation, Biochemical analysis, Capillary flow, Enzyme-catalyzed precipitation, Microfluidic method, Precipitation reaction, Single use, capillary force, device fabrication, lab-chip, microfluidic chip