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Journal Article
Prediction of the Limit of Detection of an Optical Resonant Reflection Biosensor
- Authors
- Jong Cheol Hong, Kyung-Hyun Kim, Jae-Heon Shin, Chul Huh, Gun Yong Sung
- Issue Date
- 2007-07
- Citation
- Optics Express, v.15, no.14, pp.8972-8978
- ISSN
- 1094-4087
- Publisher
- Optical Society of America(OSA)
- Language
- English
- Type
- Journal Article
- Abstract
- A prediction of the limit of detection of an optical resonant reflection biosensor is presented. An optical resonant reflection biosensor using a guided-mode resonance filter is one of the most promising label-free optical immunosensors due to a sharp reflectance peak and a high sensitivity to the changes of optical path length. We have simulated this type of biosensor using rigorous coupled wave theory to calculate the limit of detection of the thickness of the target protein layer. Theoretically, our biosensor has an estimated ability to detect thickness change approximately the size of typical antigen proteins. We have also investigated the effects of the absorption and divergence of the incident light on the detection ability of the biosensor. © 2007 Optical Society of America.
- KSP Keywords
- Detection ability, Guided mode resonance filter(GMRF), Guided-mode resonance(GMR), High Sensitivity, Label-Free, Limit of detection, Optical path length, Resonant reflection, Rigorous coupled wave theory, Sensitivity to, Target protein
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
