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Conference Paper
A Hub-protein based Visualization of Large Protein-Protein Interaction Networks
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- Authors
- Sun Lee Bang, Jae Hun Choi, Jong Min Park, Soo-Jun Park
- Issue Date
- 2007-08
- Citation
- International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2007, pp.1217-1220
- Publisher
- IEEE
- Language
- English
- Type
- Conference Paper
- Abstract
- According as the protein-protein interaction (PPI) data more increase, we need to optimally visualize them as network, in that describing the relationship among proteins is able to easily analyze biological processes happened in a cell. In this paper, to fast layout large-scale PPI networks, we proposed a method taking hub-proteins into consideration, which have more interactions than any other proteins in a network. In other words, it enforces two core parts of Walshaw's multilevel force-directed placement algorithm (MLFDP) to be modified. The modification is achieved by coarsening and expanding all neighboring proteins of hub-protein just once, whereas only two proteins in Walshaw's method. Our experiments show that the quality of layout is better optimal and time cost is reduced up to 63% in comparison with other methods. © 2007 IEEE.
- KSP Keywords
- Biological Processes, Force-directed placement, Hub-proteins, PPI networks, Placement algorithm, Protein-protein interaction networks, large-scale, time cost