상세정보
학술지
Lack of Promotion of Mammary, Lung and Skin Tumorigenesis by 20 kHz Triangular Magnetic Fields
- 저자
- 이해준, 최수용, 장자준, 김윤명, 백정기, 최형도, 김남, 이윤실
- 발행일
- 200709
- 출처
- Bioelectromagnetics, v.28 no.6, pp.446-453
- ISSN
- 0197-8462
- 출판사
- John Wiley & Sons
- 협약과제
- 07MR1500, 전자파 영향 및 표준화 연구, 최형도
- 초록
- In order to evaluate possible tumorigenic effects of a 20 kHz intermediate frequency triangular magnetic field (IF), a frequency emitted from TV and PC monitors at 6.25 μT rms, which is the regulated exposure limit of magnetic field for the public in Korea, mammary tumors were produced in female Sprague-Dawley rats by oral intubation of dimethylbenz(a)anthracene (DMBA), lung tumors in ICR mice by scapular region injection of benzo(a)pyrene (BP), and skin tumors in female ICR mice by topical application of DMBA and tetradecanoylphorbolester (TPA). IF was applied 8 h/day for 14 weeks beginning the day after DMBA treatment for mammary tumor experiment, for 6 weeks after weaning for lung tumor, and for 20 weeks beginning 1 week after DMBA application for skin tumor experiment. For skin tumors, TPA was applied once a week for 19 weeks. Results showed no significant differences in tumor incidence, mean tumor number and volume, and histological patterns between IF magnetic-field exposed and sham control rats in the above three tumor models. Therefore, we conclude that within the limitation or number of animals and the experimental conditions, 20 kHz IF triangular magnetic field exposure of 6.25 μT does not appear to be a strong co-tumorigenic agent in the chosen murine mammary, lung and skin models. © 2007 Wiley-Liss, Inc.
- KSP 제안 키워드
- Exposure limit, Intermediate frequency, Lung tumor, Magnetic field(MF), Mammary tumor, Skin tumor, Sprague-Dawley rats, magnetic field exposure, topical application, tumor models