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Conference Paper Plastic Extended Optical-Path-Length Absorbance Detection Microchip For On-Chip Prostate Specific Antigen (PSA) Quantification
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Authors
Dae-Sik Lee, Song Hyun Woo, Yo Han Choi, Chung Kwang Hyo, Jung Moon Youn, Park Seon Hee
Issue Date
200810
Source
SENSORS 2008, pp.262-265
DOI
https://dx.doi.org/10.1109/ICSENS.2008.4716431
Project Code
08MC2500, Ubiquitous Health Monitoring Module and System Development, Park Seon Hee
Abstract
This paper reports a new polymer extended opticalpath-length absorbance-based detecting device for quantification of free PSA for point-of-care testing. The plastic COC device was fabricated using the polymer micromachining protocols, including multi-stage silicon molder, replica-molding and photolithographic protocols. The plastic-based microdevice incorporated with optical functions including micromirrors with minimum dead volume and a huge extended optical path length of 2 mm, which is the dimension in enzyme-linked immunosorbent assay (ELISA). We demonstrated the quantitative detection of free PSA, a prostate cancer biomarker, in range of 1~10 ng/ml on microchip with a 3 μl-volume chamber after positive and negative control tests. © 2008 IEEE.
KSP Keywords
2 mm, Absorbance detection, Cancer biomarker, Dead volume, Detecting device, Multi-stage, On-chip, Optical function, Optical path length, Point-of-Care testing, Positive and negative