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Journal Article Enhanced Protein Immobilization Efficiency on a TiO2 Surface Modified with a Hydroxyl Functional Group
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Authors
Wan Joong Kim, Sang Hee Kim, Bong Soo Lee, An Soon Kim, Chil Seong Ah, Chul Huh, Gun Yong Sung, Wan Soo Yun
Issue Date
2009-10
Citation
Langmuir, v.25, no.19, pp.11692-11697
ISSN
0743-7463
Publisher
American Chemical Society(ACS)
Language
English
Type
Journal Article
DOI
https://dx.doi.org/10.1021/la901615e
Project Code
08MC2500, Ubiquitous Health Monitoring Module and System Development, Park Seon Hee
Abstract
An antibody immobilization was investigated using a self-assembled monolayer (SAM) over the highly refractive coatings with a SiO2, TiO2, or Si3N4 substrate. The immobilization was characterized by analyzing the hydrophilic properties of hydroxyl (OH) groups on surface coatings with contact angle (CA) measurements to enhance protein immobilization. The hydroxyl (OH) group was formed in greater amounts as the oxygen plasma exposure time was increased, which resulted in a large enhancement in antibody immobilization. It indicated that hydroxyl (OH) group formation is critical for developing a label-free optical transducer with a high sensitivity. © 2009 American Chemical Society.
KSP Keywords
Contact angle(CA), Exposure time, Group Formation, High Sensitivity, Hydrophilic properties, Hydroxyl functional group, Label-Free, Optical transducer, Refractive coatings, Surface-modified, antibody immobilization