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A Surface Acoustic Wave-Based Immunosensing Device Using a Nanocrystalline ZnO Film on Si
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- Authors
- Dae Sik Lee, Jun Hwang Lee, Jikui Luo, Yongqing Fu, William I. Milne, Sungl Yul Maeng, Mun Yeon Jung, Sun Hee Park, Hyun C. Yoon
- Issue Date
- 2009-10
- Citation
- Journal of Nanoscience and Nanotechnology, v.9, no.12, pp.7181-7185
- ISSN
- 1533-4880
- Publisher
- American Scientific Publishers (ASP)
- Language
- English
- Type
- Journal Article
- Abstract
- The novelty of this study resides in the fabrication of a bio-sensing device, based on the surface acoustic wave (SAW) on a nanocrystalline ZnO film. The ZnO film was deposited using an rf magnetron sputtering at room temperature on silicon. The deposited films showed the c-axisoriented crystallite with grain size of ~40 nm. The immunosensing device was fabricated using photolithographic protocols on the film. As a model biomolecular recognition and immunosensing, biospecific interaction between a 6-(2,4-dinitrophenyl) aminohexanoic acid (DNP) antigen and its antibody was employed, demonstrating the shifts of resonant frequencies on SAW immunosensing device. The device exhibited a linearity as a function of the antibody concentration in the range of 20~20,000 ng/ml. © 2009 American Scientific Publishers. All rights reserved.
- KSP Keywords
- 40 nm, Bio-Sensing, Biomolecular recognition, Biospecific interaction, Grain size, Nanocrystalline ZnO, Resonant frequency(Fr), Room-temperature, Sensing device, Surface acoustic wave(SAW), ZnO films