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Easy Detection of Amyloid β-Protein Using Photo-Sensitive Field Effect
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- Authors
- Kwan-Soo Kim, Jongil Ju, Ki-Bong Song
- Issue Date
- 2012-10
- Citation
- 센서학회지, v.21, no.5, pp.339-344
- ISSN
- 1225-5475
- Publisher
- 한국센서학회
- Language
- English
- Type
- Journal Article
- Abstract
- This article describes a novel method for the detection of amyloid-${\beta}$($A{\beta}$) peptide that utilizes a photo-sensitive field-effect transistor (p-FET). According to a recent study, $A{\beta}$ protein has been known to play a central role in the pathogenesis of Alzheimer's disease (AD). Accordingly, we investigated the variation of photo current generated from p-FET with and without intracellular magnetic beads conjugated with $A{\beta}$ peptides, which are placed on the p-FET sensing areas. The decrease of photo current was observed due to the presence of the magnetic beads on the channel region. Moreover, a similar characteristic was shown when the Raw 264 cells take in magnetic beads treated with $A{\beta}$ peptide. This means that it is possible to simply detect a certain protein using magnetic beads and a p-FET device. Therefore, in this paper, we suggest that our method could detect tiny amounts of $A{\beta}$ for early diagnosis of AD using the p-FET devices.
- KSP Keywords
- Alzheimer's Disease(AD), Early diagnosis, Easy detection, FET devices, FET sensing, Field-effect transistors(FETs), Magnetic beads(MBs), Photo-sensitive, novel method