상세정보
학술지
Gain-Switched Ti:Sapphire Laser-based Photoacoustic Imaging
- 발행일
- 201607
- 출처
- Applied Optics, v.55 no.20, pp.5419-5422
- ISSN
- 1559-128X
- 출판사
- Optical Society of America (OSA)
- 협약과제
- 15PC2100, 유방암수술시 전이부위 실시간 판독이 가능한 형광(심도>10mm)및 광음향(분해능<60um@30Mhz,심도>60mm@10MHz)융합 프로브 기술 개발, 김봉규
- 초록
- We demonstrate photoacoustic (PA) imaging using a compact gain-switched Ti:sapphire laser. Additionally, a simple laser configuration is provided. The Ti:sapphire laser is pumped using a frequency-doubled pulsed neodymium-doped yttrium aluminum garnet pulse laser operating at a repetition rate of 10 Hz, with a pump energy of 37 mJ. No water cooling is required for the Ti:sapphire crystal. The output pulse energy and pulse duration of the laser are 13.6 mJ and 11 ns, respectively. Thus, the power conversion efficiency is 36.7%. As the end mirror in a laser cavity is adjusted in a horizontal direction, the output wavelength can be tuned within a range of 725-880 nm with a spectral bandwidth of approximately 1 nm. The laser has a small footprint size of 50 cm x 35cm including even laser pumping. Because the near-infrared region has significant advantages in the context of absorption and scattering in biological tissues, our laser can be used for PA imaging. Apart from obtaining PA images of a tube filled with indocyanine green immersed in water and placed under chicken breast tissue, our laser system could also be used for the simultaneous PA and ultrasound (US) dual-modality imaging of blood vessels lying beneath the skin of a human middle finger. We used a commercially available US machine for the PA and US dual-modality imaging.
- KSP 제안 키워드
- Absorption and scattering, Blood Vessels, Breast tissue, Chicken breast, Conversion efficiency(C.E.), Frequency-doubled, Human middle finger, Laser cavity, Near-Infrared(NIR), Near-infrared region, Neodymium-doped yttrium aluminum garnet