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Gain-Switched Ti:Sapphire Laser-based Photoacoustic Imaging
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- Authors
- Jisu Lee, Yong-Jae Lee, Eun Ju Jeong, Moon Youn Jung, Susung Lee, Bong Kyu Kim, Dong Hoon Song
- Issue Date
- 2016-07
- Citation
- Applied Optics, v.55, no.20, pp.5419-5422
- ISSN
- 1559-128X
- Publisher
- Optical Society of America (OSA)
- Language
- English
- Type
- Journal Article
- Abstract
- We demonstrate photoacoustic (PA) imaging using a compact gain-switched Ti:sapphire laser. Additionally, a simple laser configuration is provided. The Ti:sapphire laser is pumped using a frequency-doubled pulsed neodymium-doped yttrium aluminum garnet pulse laser operating at a repetition rate of 10 Hz, with a pump energy of 37 mJ. No water cooling is required for the Ti:sapphire crystal. The output pulse energy and pulse duration of the laser are 13.6 mJ and 11 ns, respectively. Thus, the power conversion efficiency is 36.7%. As the end mirror in a laser cavity is adjusted in a horizontal direction, the output wavelength can be tuned within a range of 725-880 nm with a spectral bandwidth of approximately 1 nm. The laser has a small footprint size of 50 cm x 35cm including even laser pumping. Because the near-infrared region has significant advantages in the context of absorption and scattering in biological tissues, our laser can be used for PA imaging. Apart from obtaining PA images of a tube filled with indocyanine green immersed in water and placed under chicken breast tissue, our laser system could also be used for the simultaneous PA and ultrasound (US) dual-modality imaging of blood vessels lying beneath the skin of a human middle finger. We used a commercially available US machine for the PA and US dual-modality imaging.
- KSP Keywords
- Absorption and scattering, Biological tissues, Blood Vessels, Breast tissue, Chicken breast, Conversion efficiency(C.E.), Frequency-doubled, Gain-switched, Human middle finger, Laser cavity, Near-infrared region