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Journal Article
A Three-Dimensional and Bevel-Angled Ultrahigh Aspect Ratio Microneedle for Minimally Invasive and Painless Blood Sampling
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- Authors
- Dae-Sik Lee, Cheng Guo Li, Chunhwa Ihm, Hyungil Jung
- Issue Date
- 2018-02
- Citation
- Sensors and Actuators B : Chemical, v.255, pp.384-390
- ISSN
- 0925-4005
- Publisher
- Elsevier
- Language
- English
- Type
- Journal Article
- Abstract
- In spite of the invasiveness and pain related with it, blood sampling is necessary in point-of-care systems to obtain biochemical information. In this context, a substitute micro-scale needle for minimally invasive and painless blood sampling has been developed. In conventional microneedle fabrication methods, it is difficult to combine the features of a sharp tip shape, appropriate length, and a hollow structure simultaneously. Thus, here we report a sharp, hollow, and ultrahigh aspect ratio microneedle long enough to get to the blood vessels which is capable of minimizing the pain caused by nerve pricking. It is equipped with a fluidic system to handle blood. The structure of the microneedle was precisely formed using a drawing lithography method and a sharp angle tip was formed using a laser-cutting method.
- KSP Keywords
- Blood sampling, Blood vessel, Cutting method, Fabrication method, Fluidic system, Hollow structure, Laser-cutting, Micro-scale, Minimally invasive, Point-of-care, Sharp angle