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학술지 In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products
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저자
심주용, 안창근, 정은주, 김봉규
발행일
201801
출처
Scientific Reports, v.8, pp.1-11
ISSN
2045-2322
출판사
Nature Publishing Group
DOI
https://dx.doi.org/10.1038/s41598-018-19340-y
협약과제
17ZS1300, 광간섭계 기반의 광음향 기술을 이용한 무채혈 혈당분석 원천기술 , 김봉규
초록
Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals. Our raster-scan imaging showed that the skin condition for in vivo spectroscopic glucose monitoring had significant inhomogeneities and large variability in the probing area where the signal was acquired. However, the selective localization of the probing led to a reduction in the effects of variability due to the skin secretion product. Looking forward, this technology has broader applications not only in continuous glucose monitoring for diabetic patient care, but in forensic science, the diagnosis of malfunctioning sweat pores, and the discrimination of tumors extracted via biopsy.
KSP 제안 키워드
Blood glucose level, Continuous glucose monitoring, Diabetic Patient, Excitation light, Forensic science, Hand washing, High absorption, Infrared Spectra, Infrared excitation, Infrared photoacoustic spectroscopy, Mid-infrared(MIR)