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Journal Article A Microheater on Polyimide Substrate for Hand-held Realtime Microfluidic Polymerase Chain Reaction Amplification
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Authors
Dae-Sik Lee, Ok Ran Choi, Yujin Seo
Issue Date
2019-12
Citation
Micro and Nano Systems Letters, v.7, no.1, pp.1-4
ISSN
2213-9621
Publisher
The Society of Micro and Nano Systems Letters
Language
English
Type
Journal Article
DOI
https://dx.doi.org/10.1186/s40486-019-0098-1
Abstract
The development of a DNA microfluidic device with a high speed, low power, and low reagent volume is very critical for real-time genotyping and diagnosis in point-of-care applications. This paper reports a polymer-based thermal cycler for a handheld and battery-powered polymerase chain reaction (PCR) system using a polyimide (PI) film-based micro-fabricated heater module and polymer film microfluidic chambers of 10 μL, with a handheld and low power consumption, compared to state of the art. It took 21혻min for 40 thermal cycling for DNA amplification and a maximum power consumption of 0.6혻W. The microheater on PI film substrate fabricated and real-time quantification of deoxyribonucleic acid (DNA) using the heater in hand-held sizes experimentally shown here. The device would be applicable for on-site molecular diagnostics.
KSP Keywords
DNA amplification, Hand-held, High Speed, Micro-fabricated, Microfluidic chambers, Microfluidic device, On-Site, Point-of-care, Polyimide (PI) film, Polyimide substrate, Polymer films
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
CC BY