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학술지 A Microheater on Polyimide Substrate for Hand-held Realtime Microfluidic Polymerase Chain Reaction Amplification
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저자
이대식, 최옥란, 서유진
발행일
201912
출처
Micro and Nano Systems Letters, v.7 no.1, pp.1-4
ISSN
2213-9621
출판사
The Society of Micro and Nano Systems Letters
DOI
https://dx.doi.org/10.1186/s40486-019-0098-1
협약과제
19JS1100, 다중 바이오마커 기반 모바일 다이어트 모니터링 기술 개발, 이대식
초록
The development of a DNA microfluidic device with a high speed, low power, and low reagent volume is very critical for real-time genotyping and diagnosis in point-of-care applications. This paper reports a polymer-based thermal cycler for a handheld and battery-powered polymerase chain reaction (PCR) system using a polyimide (PI) film-based micro-fabricated heater module and polymer film microfluidic chambers of 10 μL, with a handheld and low power consumption, compared to state of the art. It took 21혻min for 40 thermal cycling for DNA amplification and a maximum power consumption of 0.6혻W. The microheater on PI film substrate fabricated and real-time quantification of deoxyribonucleic acid (DNA) using the heater in hand-held sizes experimentally shown here. The device would be applicable for on-site molecular diagnostics.
KSP 제안 키워드
DNA amplification, Hand-held, High Speed, Micro-fabricated, Microfluidic chamber, Microfluidic device, On-Site, Point-of-care, Polyimide (PI) film, Polyimide substrate, Polymer films
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