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학술지 Barium Titanate Nanoparticles Sensitise Treatment-Resistant Breast Cancer Cells to the Antitumor Action of Tumour-Treating Fields
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저자
윤이나, 이대식, 박형주, 김재성
발행일
202002
출처
Scientific Reports, v.10, pp.1-9
ISSN
2045-2322
출판사
Nature Research
DOI
https://dx.doi.org/10.1038/s41598-020-59445-x
협약과제
19ZS1400, 전기장을 이용한 입는 암치료기, 이대식
초록
Although tumour-treating fields (TTFields) is a promising physical treatment modality based on disruption of dipole alignments and generation of dielectrophoretic forces during cytokinesis, not much is known about TTFields-responsive sensitisers. Here, we report a novel TTFields-responsive sensitiser, barium titanate nanoparticles (BTNPs), which exhibit cytocompatibility, with non-cytotoxic effects on breast cancer cells. BTNPs are characterised by high dielectric constant values and ferroelectric properties. Notably, we found that BTNPs sensitised TTFields-resistant breast cancer cells in response to TTFields. In addition, BTNPs accumulated in the cytoplasm of cancer cells in response to TTFields. Further, we showed that TTFields combined with BTNPs exhibited antitumor activity by modulating several cancer-related pathways in general, and the cell cycle-related apoptosis pathway in particular. Therefore, our data suggest that BTNPs increase the antitumor action of TTFields by an electric field-responsive cytosolic accumulation, establishing BTNP as a TTFields-responsive sensitiser.
KSP 제안 키워드
Apoptosis pathway, Barium titanate nanoparticles, Breast Cancer(BC), Cytotoxic effects, Ferroelectric properties, High dielectric constant, Non-cytotoxic, antitumor activity, breast cancer cells, cell cycle, electric field
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