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Journal Article
A Novel Three-dimensional Magnetic Particle Imaging System based on the Frequency Mixing for the Point-of-care Diagnostics
- Authors
- Seung-Min C hoi, Jae-Chan Jeong, Jinsun Kim, Eul-Gyoon Lim, Chang-beom Kim, Sang-Jin Park, Dae-Yong Song, Hans-Joachim Krause, Hyobong Hong, In So Kweon
- Issue Date
- 2020-07
- Citation
- Scientific Reports, v.10, pp.1-16
- ISSN
- 2045-2322
- Publisher
- Nature Research
- Language
- English
- Type
- Journal Article
- Abstract
- The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is 20×33×45cm3 in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is 0.13μL, 10혻mg/mL, 1.3μg (Fe).
- KSP Keywords
- Biomedical diagnostics, Detection Method, Detection limit, Field free line, Hybrid field, Non-radioactive, Point-of-Care testing, Point-of-care diagnostics, Power Consumption, Radioactive tracers, Superparamagnetic iron oxide(SPIO)
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
