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학술지 Behavioral Changes and Gene Profile Alterations after Chronic 1,950-MHz Radiofrequency Exposure: An Observation in C57BL/6 Mice
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정예지, 손영훈, 최형도, 김남, 이윤실, 고영규, 이해준
Brain and Behavior, v.10 no.11, pp.1-10
20HH3900, 복합 전파환경에서의 국민건강 보호 기반 구축 사업, 최형도
Introduction: Due to public concerns about deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMF), the potential effects of RF-EMF on the central nervous system have received wide consideration. Methods: Here, two groups of C57BL/6 mice, aged 2 and 12혻months, were exposed to 1,950-MHz RF-EMF at a specific absorption rate of 5.0혻W/kg for chronic periods (2혻hr/day and 5혻days/week for 8혻months). Behavioral changes were then assessed in the mice at 10혻months (sham- or RF-10M) and 20혻months (sham- or RF-20M), on the open-field test, the Y-maze test, and an object recognition memory task, while biological effects were analyzed via microarray gene profiling of the hippocampus. Results: Open-field test results showed a decrease in the time duration spent at the center while there was a decrease in enhanced memory shown by the Y-maze test and the novel object recognition test in the RF-20M mice, compared to sham-exposed mice, but no significant changes in the RF-10M group. Based on a 2-fold change cutoff, the microarray data revealed that 15 genes, which are listed as being involved in neurogenesis on Gene Ontology, were altered in both groups. Quantitative real-time PCR for validation showed increased expression of Epha8 and Wnt6 in the hippocampi of RF-20M group mice, although 13 additional genes showed no significant changes following RF-EMF exposure. Conclusion: Therefore, cognitive enhancement following chronic exposure for 8혻months to RF-EMF from middle age may be associated with increases in neurogenesis-related signals in the hippocampus of C57BL/6 mice.
KSP 제안 키워드
Behavioral changes, C57BL/6 mice, Central Nervous System(CNS), Cognitive enhancement, EMF exposure, Electromagnetic Field, Field Test, Gene ontology, Gene profiling, Microarray Data, Middle age