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Journal Article
Behavioral changes and gene profile alterations after chronic 1,950‐MHz radiofrequency exposure: An observation in C57BL/6 mice
- Authors
- Ye Ji Jeong, Yeonghoon Son, Hyung-Do Choi, Nam Kim, Yun-Sil Lee, Young-Gyu Ko, Hae-June Lee
- Issue Date
- 2020-11
- Citation
- Brain and Behavior, v.10, no.11, pp.1-10
- ISSN
- 2162-3279
- Publisher
- Wiley
- Language
- English
- Type
- Journal Article
- Abstract
- Introduction: Due to public concerns about deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMF), the potential effects of RF-EMF on the central nervous system have received wide consideration. Methods: Here, two groups of C57BL/6 mice, aged 2 and 12혻months, were exposed to 1,950-MHz RF-EMF at a specific absorption rate of 5.0혻W/kg for chronic periods (2혻hr/day and 5혻days/week for 8혻months). Behavioral changes were then assessed in the mice at 10혻months (sham- or RF-10M) and 20혻months (sham- or RF-20M), on the open-field test, the Y-maze test, and an object recognition memory task, while biological effects were analyzed via microarray gene profiling of the hippocampus. Results: Open-field test results showed a decrease in the time duration spent at the center while there was a decrease in enhanced memory shown by the Y-maze test and the novel object recognition test in the RF-20M mice, compared to sham-exposed mice, but no significant changes in the RF-10M group. Based on a 2-fold change cutoff, the microarray data revealed that 15 genes, which are listed as being involved in neurogenesis on Gene Ontology, were altered in both groups. Quantitative real-time PCR for validation showed increased expression of Epha8 and Wnt6 in the hippocampi of RF-20M group mice, although 13 additional genes showed no significant changes following RF-EMF exposure. Conclusion: Therefore, cognitive enhancement following chronic exposure for 8혻months to RF-EMF from middle age may be associated with increases in neurogenesis-related signals in the hippocampus of C57BL/6 mice.
- KSP Keywords
- Behavioral changes, C57BL/6 mice, Central Nervous System(CNS), Cognitive enhancement, EMF Exposure, Electromagnetic Field(EMF), Field Test, Gene profiling, Microarray Data, Middle age, Novel object recognition
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
