상세정보
학술지
Spread Spectrum SERS Allows Label-free Detection of Attomolar Neurotransmitters
- 발행일
- 202101
- 출처
- Nature Communications, v.12, pp.1-10
- ISSN
- 2041-1723
- 출판사
- Nature Research
- 협약과제
- 18HS1900, 고품질 생체정보 획득 분석을 위한 단층 이미징 및 인식 센서 기술 연구, 채병규
- 초록
- The quantitative label-free detection of neurotransmitters provides critical clues in understanding neurological functions or disorders. However, the identification of neurotransmitters remains challenging for surface-enhanced Raman spectroscopy (SERS) due to the presence of noise. Here, we report spread spectrum SERS (ss-SERS) detection for the rapid quantification of neurotransmitters at the attomolar level by encoding excited light and decoding SERS signals with peak autocorrelation and near-zero cross-correlation. Compared to conventional SERS measurements, the experimental result of ss-SERS shows an exceptional improvement in the signal-to-noise ratio of more than three orders of magnitude, thus achieving a high temporal resolution of over one hundred times. The ss-SERS measurement further allows the attomolar SERS detection of dopamine, serotonin, acetylcholine, 款-aminobutyric acid, and glutamate without Raman reporters. This approach opens up opportunities not only for investigating the early diagnostics of neurological disorders or highly sensitive biomedical SERS applications but also for developing low-cost spectroscopic biosensing applications.
- KSP 제안 키워드
- Cross-Correlation, Experimental Result, High temporal resolution, Highly sensitive, Label-Free Detection, Low-cost, Neurological disorders, Orders of magnitude, SERS detection, Signal noise ratio(SNR), Signal-to-Noise
본 저작물은 크리에이티브 커먼즈 저작자 표시 (CC BY) 조건에 따라 이용할 수 있습니다.
