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Journal Article
Spread Spectrum SERS Allows Label-free Detection of Attomolar Neurotransmitters
- Authors
- Wonkyoung Lee, Byoung-Hoon Kang, Hyunwoo Yang, Moonseong Park, Ji Hyun Kwak, Taerin Chung, Yong Jeong, Bong Kyu Kim, Ki-Hun Jeong
- Issue Date
- 2021-01
- Citation
- Nature Communications, v.12, pp.1-10
- ISSN
- 2041-1723
- Publisher
- Nature Research
- Language
- English
- Type
- Journal Article
- Abstract
- The quantitative label-free detection of neurotransmitters provides critical clues in understanding neurological functions or disorders. However, the identification of neurotransmitters remains challenging for surface-enhanced Raman spectroscopy (SERS) due to the presence of noise. Here, we report spread spectrum SERS (ss-SERS) detection for the rapid quantification of neurotransmitters at the attomolar level by encoding excited light and decoding SERS signals with peak autocorrelation and near-zero cross-correlation. Compared to conventional SERS measurements, the experimental result of ss-SERS shows an exceptional improvement in the signal-to-noise ratio of more than three orders of magnitude, thus achieving a high temporal resolution of over one hundred times. The ss-SERS measurement further allows the attomolar SERS detection of dopamine, serotonin, acetylcholine, 款-aminobutyric acid, and glutamate without Raman reporters. This approach opens up opportunities not only for investigating the early diagnostics of neurological disorders or highly sensitive biomedical SERS applications but also for developing low-cost spectroscopic biosensing applications.
- KSP Keywords
- Cross-Correlation, Experimental Result, High temporal resolution, Highly sensitive, Label-Free Detection, Low-cost, Neurological disorders, Orders of magnitude, SERS detection, Signal noise ratio(SNR), Signal-to-Noise
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
