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Collaborative multi-modal deep learning and radiomic features for classification of strokes within 6 h
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- Authors
- Chiho Yoon, Sampa Misra, Kwang-Ju Kim, Chulhong Kim, Bum Joon Kim
- Issue Date
- 2023-10
- Citation
- Expert Systems with Applications, v.228, pp.1-9
- ISSN
- 0957-4174
- Publisher
- Elsevier Ltd.
- Language
- English
- Type
- Journal Article
- Abstract
- Clinicians use imaging-based acute stroke onset time (SOT) to make crucial decisions regarding stroke treatments, such as thrombolysis or thrombectomy. Patients may receive intravenous thrombolysis and undergo endovascular thrombectomy (EVT) within 3 or 4.5 h and 6 h from SOT, respectively. Most of the classification algorithms developed so far classify SOT within 4.5 h for thrombolysis. In this study, we demonstrated a deep learning (DL) method to classify SOT within 6 h to identify patients requiring EVT. We developed a DL-based segmentation model using a multi-modal UNet (MM-UNet) to predict the region of interest (ROI) from magnetic resonance (MR) images. Radiomic features were extracted from the MR images and ROI. Additionally, we proposed a DL model to extract hidden representations (deep features) using the MM-UNet and ResNet-18 models. We found that the classification performance improved by combining radiomic and deep features. The cross-validation results indicate that our proposed method sufficiently classified SOT within 6 h, achieving an F0.5 score of 80.6%. The DL model using multi-modal MR images can potentially become a practical decision-support tool for stroke treatments.
- KSP Keywords
- Acute stroke, Classification Performance, Classification algorithm, Cross validation(CV), DL model, Decision support tool, Intravenous thrombolysis, MR Images, Magnetic resonance(MR), Multi-modal, Onset time