This simulation study aims to differentiate between contrast media and calcification in blood vessel using the effective atomic number (EAN) extraction method in electromagnetic X-ray computed tomography (CT) imaging. Calibration was performed on six tissue-equivalent materials, three contrast medium, and one calcium solution. The Hounsfield unit (HU) values at 80 kV and 140 ㎸ with electromagnetic spectrum using dualenergy computed tomography (DECT) facilitated this calibration. EAN from the polynomial method was then compared with that from the Stoichiometric method. In 120 ㎸ vascular imaging, when the HU of calcium and iodine contrast media were alike, EAN provided a more pronounced contrast than HU. The iodine contrast agent’s enhancement in EAN was approximately 30.0 %, and in HU, it was 13.0 % relative to calcium. This indicates EAN’s potential to better differentiate contrast media from calcification in clinical contexts.
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