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Journal Article
Magnetic nanoparticle spectroscopy for multiplex detection: Insights from frequency mixing magnetic detection
- Authors
- Ali Mohammad Pourshahidi, Jae Chan Jeong, Hans-Joachim Krause, Hyo Bong Hong
- Issue Date
- 2025-12
- Citation
- Sensors and Actuators A: Physical, v.396, pp.1-8
- ISSN
- 0924-4247
- Publisher
- Elsevier
- Language
- English
- Type
- Journal Article
- Abstract
- Magnetic nanoparticles (MNPs) have shown promising applications in the field of biomedical sciences. Subsequently, various types of Magnetic Particle Spectroscopy (MPS) have been proposed for quantitative and qualitative analysis of MNPs. Among the various functions of MPS proposed so far, the development of technology that can analyze multiplex detection of different types of MNPs has attracted due to the expansion of various application fields. For example, the technology can be applied to enhance efficiency in biosensors, process analysis in MNP manufacturing, and measurement of various diseases in MPI. In our investigation, we perform a comparative study of different commercially available MNPs for use in multiplex detection applications using the frequency mixing magnetic detection (FMMD) technique. In this method, we employ a low-frequency magnetic field scanning method and analyze the real and imaginary parts of the measurement signal f
1 + 2·f2 obtained from binary mixture samples of different MNP type combinations. Our findings suggest that FMMD-based duplex detection can achieve effective and reliable differentiation when a substantial phase response deviation exists among the particles.
- KSP Keywords
- Application fields, Biomedical sciences, Low Frequency Magnetic Field, Magnetic Nanoparticle(MNP), Magnetic particle spectroscopy, Process analysis, Qualitative Analysis, Scanning method, binary mixture, comparative study, frequency mixing
This work is distributed under the term of Creative Commons License (CCL)
(CC BY)
(CC BY)
