The development of strain-insensitive pressure sensors represents a critical breakthrough in stretchable electronics, addressing the fundamental challenge of strain-pressure coupling that has hindered the deployment of conventional sensors on deformable surfaces. This review comprehensively examines recent advances in overcoming measurement limitations caused by simultaneous pressure and strain stimuli in applications such as wearable health monitoring, soft robotics, and human-machine inter-faces. We analyze two primary technological approaches: structural engineering strategies that physically decouple strain and pressure effects through mechanical architectures, hierarchical patterns, specialized electrode geometries, and simultaneous measurement sys-tems; and material-based solutions utilizing ionic elastomers, liquid metals, and engineered composites with intrinsic strain-inde-pendent properties. Recent innovations have demonstrated remarkable performance achievements, including high sensitivity, exceptional strain insensitivity, and robust long-term stability. This review provides insights into current limitations, emerging chal-lenges, and future directions for strain-insensitive pressure sensing technologies that will enable seamless integration of sensing capa-bilities into dynamically deforming environments.
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