Recent large language models (LLMs) require substantial computational and memory resources,
and the tradeoff between latency and throughput becomes more pronounced as input/output
sequence lengths and user concurrency increase. Traditional model-centric optimization techniques
offer limited solutions to system-level bottlenecks. In particular, in multiuser environments,
resource contention and interference between the prefill and decode stages can significantly
degrade the overall inference performance. This study highlights disaggregated prefill as a systemlevel approach to address these challenges. By decoupling the LLM inference pipeline into distinct
prefill and decode stages, and executing them independently on different accelerators, this
technique reduces the inference latency and maximizes resource utilization. We review state-ofthe-art research from 2024 to 2025 and provide a system-level architectural perspective on how
disaggregated prefill mitigates performance bottlenecks in LLM inference. The approach is analyzed
through four key technical components: (1) prefill/decode instance configuration, (2) key-value
cache transmission, (3) key-value cache management, and (4) request scheduling. Our analysis
confirms that disaggregated prefill is particularly effective in improving large-scale LLM inference
performance, especially in multiuser and heterogeneous hardware environments.
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