당뇨병성 신장질환(DKD)은 조기 고위험군 선별이 중요하지만, 기존의 추정 사구체여과율(eGFR)과 알부민뇨만으로는 초기 신장 손상과 질환 진행을 충분히 반영하기 어렵다는 한계가 있다. 본 연구에서는 선행연구에서 제시된 FN1과 ALDH2 바이오마커를 입력 변수로 사용하여, 동일한 학습(GSE96804, n=61) 및 독립 검증(GSE104948/GSE104954, n=71) 데이터셋에서 GLM, GAM, Elastic Net, TabPFN v2 네 가지 단일 모델과 Out-Of-Fold(OOF) 기반 Weighted Voting 및 Stacking 앙상블을 비교하였다. 그 결과 단일 GAM이 독립 검증 데이터셋에서 AUC 0.974로 가장 우수한 성능을 보였으며, 이는 선행연구 대비 향상된 성능을 보인다. 이러한 결과는 적은 수의 바이오마커와 제한된 데이터셋 환경에서는 모델의 복잡도를 높이기보다 데이터 특성에 적합한 단일 모델을 선택하는 것이 일반화 성능 향상에 더욱 효과적일 수 있음을 시사하며, DKD 진단을 위한 머신러닝 기반 분류 모델 설계에 유용한 근거를 제공한다.
KSP Keywords
Elastic Net, weighted voting
Copyright Policy
ETRI KSP Copyright Policy
The materials provided on this website are subject to copyrights owned by ETRI and protected by the Copyright Act. Any reproduction, modification, or distribution, in whole or in part, requires the prior explicit approval of ETRI. However, under Article 24.2 of the Copyright Act, the materials may be freely used provided the user complies with the following terms:
The materials to be used must have attached a Korea Open Government License (KOGL) Type 4 symbol, which is similar to CC-BY-NC-ND (Creative Commons Attribution Non-Commercial No Derivatives License). Users are free to use the materials only for non-commercial purposes, provided that original works are properly cited and that no alterations, modifications, or changes to such works is made. This website may contain materials for which ETRI does not hold full copyright or for which ETRI shares copyright in conjunction with other third parties. Without explicit permission, any use of such materials without KOGL indication is strictly prohibited and will constitute an infringement of the copyright of ETRI or of the relevant copyright holders.
J. Kim et. al, "Trends in Lightweight Kernel for Many core Based High-Performance Computing", Electronics and Telecommunications Trends. Vol. 32, No. 4, 2017, KOGL Type 4: Source Indication + Commercial Use Prohibition + Change Prohibition
J. Sim et.al, “the Fourth Industrial Revolution and ICT – IDX Strategy for leading the Fourth Industrial Revolution”, ETRI Insight, 2017, KOGL Type 4: Source Indication + Commercial Use Prohibition + Change Prohibition
If you have any questions or concerns about these terms of use, or if you would like to request permission to use any material on this website, please feel free to contact us
KOGL Type 4:(Source Indication + Commercial Use Prohibition+Change Prohibition)
Contact ETRI, Research Information Service Section
Privacy Policy
ETRI KSP Privacy Policy
ETRI does not collect personal information from external users who access our Knowledge Sharing Platform (KSP). Unathorized automated collection of researcher information from our platform without ETRI's consent is strictly prohibited.
[Researcher Information Disclosure] ETRI publicly shares specific researcher information related to research outcomes, including the researcher's name, department, work email, and work phone number.
※ ETRI does not share employee photographs with external users without the explicit consent of the researcher. If a researcher provides consent, their photograph may be displayed on the KSP.