상세정보
학술지
Efficient Palladium-Catalyzed Amination of Aryl Chlorides using di(dicyclohexylamino)Phenylphosphine as a PN2 Ligand
- 저자
- 김보람, 조수동, 김은정, 이인혜, 성기현, 김점종, 이상경, 윤용진
- 발행일
- 201201
- 출처
- Tetrahedron, v.68 no.1, pp.287-293
- ISSN
- 0040-4020
- 출판사
- Elsevier
- 협약과제
- 12ZK1100, 그린IT 융.복합 기술개발, 이수인
- 초록
- The palladium-catalyzed amination of a variety of aryl chlorides has been accomplished by using di(dicyclohexylamino)phenylphosphine (1) as a bulky electron-rich monoaryl phosphine ligand. The optimized condition for the palladium-catalyzed amination of aryl chloride is the followings: aniline (3.0 mmol, 1.0 equiv), chlorobenzene (3.15 mmol, 1.05 equiv), ligand 1 (1 mol %, 0.03 mmol), KOtBu (4.5 mmol, 1.5 equiv), Pd2(dba)3 (1 mol %, 0.03 mmol), and toluene as solvent at reflux temperature. We report on couplings of various amines or chloroamines with chlorobenzenes and heteroaryl chloride. © 2011 Elsevier B.V. All rights reserved.
- KSP 제안 키워드
- Aryl chlorides, Electron-rich, Optimized condition, Palladium-catalyzed amination, Phosphine ligand