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Journal Article
Efficient Palladium-Catalyzed Amination of Aryl Chlorides using di(dicyclohexylamino)Phenylphosphine as a PN2 Ligand
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- Authors
- Bo Ram Kim, Su-Dong Cho, Eun Jung Kim, In-Hye Lee, Gi Hyeon Sung, Jeum-Jong Kim, Sang-Gyeong Lee, Yong-Jin Yoon
- Issue Date
- 2012-01
- Citation
- Tetrahedron, v.68, no.1, pp.287-293
- ISSN
- 0040-4020
- Publisher
- Elsevier
- Language
- English
- Type
- Journal Article
- Abstract
- The palladium-catalyzed amination of a variety of aryl chlorides has been accomplished by using di(dicyclohexylamino)phenylphosphine (1) as a bulky electron-rich monoaryl phosphine ligand. The optimized condition for the palladium-catalyzed amination of aryl chloride is the followings: aniline (3.0 mmol, 1.0 equiv), chlorobenzene (3.15 mmol, 1.05 equiv), ligand 1 (1 mol %, 0.03 mmol), KOtBu (4.5 mmol, 1.5 equiv), Pd2(dba)3 (1 mol %, 0.03 mmol), and toluene as solvent at reflux temperature. We report on couplings of various amines or chloroamines with chlorobenzenes and heteroaryl chloride. © 2011 Elsevier B.V. All rights reserved.
- KSP Keywords
- Aryl chlorides, Electron-rich, Optimized condition, Palladium-catalyzed amination, Phosphine ligand