상세정보
학술대회
A Simple Method for Quantification of Beta-Amyloid Using the Photo-Sensitive Thin Film Transistor
- 발행일
- 201106
- 출처
- International Conference on Materials for Advanced Technologies (ICMAT) 2011, pp.58-62
- 협약과제
- 11SF1300, 생체진단 가능 시각/미각 수용체 기반 센싱 기술 개발, 송기봉
- 초록
- This paper reports a technique for quantification of beta-amyloid protein by the use of photo sensitive thin film transistor (p-TFT). In recent studies, a beta-amyloid protein has strongly related a central role of the pathogenesis of Alzheimer's disease (AD) and AD-related olfactory sensory loss. In the p-TFT, we observed the difference of the photo-current according to the presence of the particles with beta-amyloid, RAW 264.7 cells, and olfactory receptor neuron cells. The p-TFT shows the drain current reduction of about 50μA is caused by the RAW 264.7 cells with magnetic beads and beta-amyloid. Therefore, we suggest a new method of detecting small quantity of A-beta for early diagnosis of AD by using photo-sensitive thin film transistor (p-TFT) devices. © (2011) Trans Tech Publications, Switzerland.
- KSP 제안 키워드
- Alzheimer's Disease(AD), Beta-amyloid, Drain current, Early diagnosis, Magnetic beads(MBs), Neuron cells, Olfactory receptor neuron, Photo-current, Photo-sensitive, RAW 264.7 cells, Thin-Film Transistor(TFT)