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Conference Paper
Detection of Small Toxin Molecules by Si Photovoltaic Integrated Circuit
- Authors
- Chan Woo Park, Jong-Heon Yang, Chil Seong Ah, Chang-Geun Ahn, Yo Han Choi, Kwang Hyo Chung, Wan-Joong Kim, Gun Yong Sung
- Issue Date
- 2011-09
- Citation
- Eurosensors 2011, pp.912-915
- Language
- English
- Type
- Conference Paper
- Abstract
- We propose a new type of photosensitive biosensor with a CMOS compatible Si photovoltaic integrated circuit, for the high-sensitive detection of small mycotoxin molecules requiring competitive assay approach. In this work, a photodiode is connected to the gate of a field effect transistor (FET) so that the open circuit voltage (V OC) of the illuminated photodiode is transferred into the drain/source current of the FET. The sensing scheme employs competitive binding of toxin molecules (within the sample solution) and toxin-BSA conjugates (immobilized on the photodiode surface) with Au-nanoparticle-labeled antibodies, followed by silver enhancement to generate opaque structures on the photodiode surface. As the amount of toxin increases, less opaque becomes the photodiode surface resulting in a higher V OC. By monitoring the channel current of the FET whose gate is driven by the V OC, quantitative detection of Aflatoxin B1 has been achieved in the range of 0~15 ppb. © 2011 Published by Elsevier Ltd.
- KSP Keywords
- Aflatoxin B1, CMOS-compatible, Channel current, Competitive assay, Field-effect transistors(FETs), High sensitive, Integrated circuit, Open circuit voltage(VOC), Photosensitive biosensor, Sensing scheme, Silver enhancement
This work is distributed under the term of Creative Commons License (CCL)
(CC BY NC ND)
(CC BY NC ND)
