상세정보
학술대회
Detection of Small Toxin Molecules by Si Photovoltaic Integrated Circuit
- 발행일
- 201109
- 출처
- Eurosensors 2011, pp.912-915
- 협약과제
- 10MC2400, 프로그램 가능한 바이오 CMOS 전계형 소자, 성건용
- 초록
- We propose a new type of photosensitive biosensor with a CMOS compatible Si photovoltaic integrated circuit, for the high-sensitive detection of small mycotoxin molecules requiring competitive assay approach. In this work, a photodiode is connected to the gate of a field effect transistor (FET) so that the open circuit voltage (V OC) of the illuminated photodiode is transferred into the drain/source current of the FET. The sensing scheme employs competitive binding of toxin molecules (within the sample solution) and toxin-BSA conjugates (immobilized on the photodiode surface) with Au-nanoparticle-labeled antibodies, followed by silver enhancement to generate opaque structures on the photodiode surface. As the amount of toxin increases, less opaque becomes the photodiode surface resulting in a higher V OC. By monitoring the channel current of the FET whose gate is driven by the V OC, quantitative detection of Aflatoxin B1 has been achieved in the range of 0~15 ppb. © 2011 Published by Elsevier Ltd.
- KSP 제안 키워드
- Aflatoxin B1, CMOS-compatible, Channel current, Competitive assay, Field-effect transistors(FETs), High sensitive, Integrated circuit, Open circuit voltage(VOC), Photosensitive biosensor, Sensing scheme, Silver enhancement